Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) Stock Competitors & Peer Comparison

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, VRTX has a market cap of 130.8B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while VRTX trades at $515.44.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas VRTX's P/E ratio is 27.09. In terms of profitability, IONS's ROE is -1.11%, compared to VRTX's ROE of +0.23%. Regarding short-term risk, IONS is more volatile compared to VRTX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check VRTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, REGN has a market cap of 80.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while REGN trades at $781.49.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas REGN's P/E ratio is 17.13. In terms of profitability, IONS's ROE is -1.11%, compared to REGN's ROE of +0.14%. Regarding short-term risk, IONS is more volatile compared to REGN. This indicates higher risk in terms of short-term price fluctuations for IONS.Check REGN's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, VRNA has a market cap of 72.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while VRNA trades at $106.91.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas VRNA's P/E ratio is -102.80. In terms of profitability, IONS's ROE is -1.11%, compared to VRNA's ROE of -0.02%. Regarding short-term risk, IONS is more volatile compared to VRNA. This indicates higher risk in terms of short-term price fluctuations for IONS.Check VRNA's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ARGX has a market cap of 61.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ARGX trades at $984.39.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ARGX's P/E ratio is 88.84. In terms of profitability, IONS's ROE is -1.11%, compared to ARGX's ROE of +0.24%. Regarding short-term risk, IONS is more volatile compared to ARGX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ARGX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, MRNA has a market cap of 57.1B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while MRNA trades at $143.97.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas MRNA's P/E ratio is -17.67. In terms of profitability, IONS's ROE is -1.11%, compared to MRNA's ROE of -0.39%. Regarding short-term risk, IONS is less volatile compared to MRNA. This indicates lower risk in terms of short-term price fluctuations for IONS.Check MRNA's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, RVMDW has a market cap of 44.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while RVMDW trades at $11.29.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas RVMDW's P/E ratio is -1.28. In terms of profitability, IONS's ROE is -1.11%, compared to RVMDW's ROE of -0.96%. Regarding short-term risk, IONS is less volatile compared to RVMDW. This indicates lower risk in terms of short-term price fluctuations for IONS.Check RVMDW's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, RVMD has a market cap of 43.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while RVMD trades at $203.77.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas RVMD's P/E ratio is -23.10. In terms of profitability, IONS's ROE is -1.11%, compared to RVMD's ROE of -0.96%. Regarding short-term risk, IONS is less volatile compared to RVMD. This indicates lower risk in terms of short-term price fluctuations for IONS.Check RVMD's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, SGEN has a market cap of 43.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while SGEN trades at $228.74.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas SGEN's P/E ratio is -57.19. In terms of profitability, IONS's ROE is -1.11%, compared to SGEN's ROE of -0.21%. Regarding short-term risk, IONS is more volatile compared to SGEN. This indicates higher risk in terms of short-term price fluctuations for IONS.Check SGEN's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ONC has a market cap of 37B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ONC trades at $346.51.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ONC's P/E ratio is 61.01. In terms of profitability, IONS's ROE is -1.11%, compared to ONC's ROE of +0.14%. Regarding short-term risk, IONS is more volatile compared to ONC. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ONC's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ALNY has a market cap of 33.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ALNY trades at $248.68.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ALNY's P/E ratio is 44.81. In terms of profitability, IONS's ROE is -1.11%, compared to ALNY's ROE of +0.94%. Regarding short-term risk, IONS is more volatile compared to ALNY. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ALNY's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ROIV has a market cap of 29.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ROIV trades at $40.82.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ROIV's P/E ratio is -38.82. In terms of profitability, IONS's ROE is -1.11%, compared to ROIV's ROE of -0.06%. Regarding short-term risk, IONS is more volatile compared to ROIV. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ROIV's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, INSM has a market cap of 28B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while INSM trades at $129.41.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas INSM's P/E ratio is -31.49. In terms of profitability, IONS's ROE is -1.11%, compared to INSM's ROE of -1.11%. Regarding short-term risk, IONS is more volatile compared to INSM. This indicates higher risk in terms of short-term price fluctuations for IONS.Check INSM's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, INCY has a market cap of 24.6B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while INCY trades at $121.47.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas INCY's P/E ratio is 16.33. In terms of profitability, IONS's ROE is -1.11%, compared to INCY's ROE of +0.30%. Regarding short-term risk, IONS is more volatile compared to INCY. This indicates higher risk in terms of short-term price fluctuations for IONS.Check INCY's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, BNTX has a market cap of 24.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while BNTX trades at $96.73.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas BNTX's P/E ratio is -12.54. In terms of profitability, IONS's ROE is -1.11%, compared to BNTX's ROE of -0.09%. Regarding short-term risk, IONS is more volatile compared to BNTX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check BNTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, UTHR has a market cap of 21.1B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while UTHR trades at $497.11.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas UTHR's P/E ratio is 17.79. In terms of profitability, IONS's ROE is -1.11%, compared to UTHR's ROE of +0.20%. Regarding short-term risk, IONS is more volatile compared to UTHR. This indicates higher risk in terms of short-term price fluctuations for IONS.Check UTHR's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, BGNE has a market cap of 20.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while BGNE trades at $184.71.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas BGNE's P/E ratio is -22.55. In terms of profitability, IONS's ROE is -1.11%, compared to BGNE's ROE of +0.14%. Regarding short-term risk, IONS is more volatile compared to BGNE. This indicates higher risk in terms of short-term price fluctuations for IONS.Check BGNE's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, GMAB has a market cap of 19.9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while GMAB trades at $32.47.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas GMAB's P/E ratio is 24.47. In terms of profitability, IONS's ROE is -1.11%, compared to GMAB's ROE of +0.14%. Regarding short-term risk, IONS is more volatile compared to GMAB. This indicates higher risk in terms of short-term price fluctuations for IONS.Check GMAB's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, DNA-WT has a market cap of 18.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while DNA-WT trades at $0.27.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas DNA-WT's P/E ratio is N/A. In terms of profitability, IONS's ROE is -1.11%, compared to DNA-WT's ROE of -0.60%. Regarding short-term risk, IONS is less volatile compared to DNA-WT. This indicates lower risk in terms of short-term price fluctuations for IONS.Check DNA-WT's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ASND has a market cap of 16.4B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ASND trades at $263.52.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ASND's P/E ratio is -108.89. In terms of profitability, IONS's ROE is -1.11%, compared to ASND's ROE of +1.90%. Regarding short-term risk, IONS is more volatile compared to ASND. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ASND's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, NBIX has a market cap of 15.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while NBIX trades at $156.22.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas NBIX's P/E ratio is 22.57. In terms of profitability, IONS's ROE is -1.11%, compared to NBIX's ROE of +0.21%. Regarding short-term risk, IONS is more volatile compared to NBIX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check NBIX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, JAZZ has a market cap of 15.4B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while JAZZ trades at $245.80.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas JAZZ's P/E ratio is 9.16. In terms of profitability, IONS's ROE is -1.11%, compared to JAZZ's ROE of +0.21%. Regarding short-term risk, IONS is more volatile compared to JAZZ. This indicates higher risk in terms of short-term price fluctuations for IONS.Check JAZZ's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, BBIO has a market cap of 14.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while BBIO trades at $72.44.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas BBIO's P/E ratio is -19.37. In terms of profitability, IONS's ROE is -1.11%, compared to BBIO's ROE of +0.32%. Regarding short-term risk, IONS is more volatile compared to BBIO. This indicates higher risk in terms of short-term price fluctuations for IONS.Check BBIO's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, EXEL has a market cap of 14.1B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while EXEL trades at $56.12.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas EXEL's P/E ratio is 16.03. In terms of profitability, IONS's ROE is -1.11%, compared to EXEL's ROE of +0.42%. Regarding short-term risk, IONS is less volatile compared to EXEL. This indicates lower risk in terms of short-term price fluctuations for IONS.Check EXEL's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, SMMT has a market cap of 14B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while SMMT trades at $17.55.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas SMMT's P/E ratio is -15.67. In terms of profitability, IONS's ROE is -1.11%, compared to SMMT's ROE of -2.04%. Regarding short-term risk, IONS is more volatile compared to SMMT. This indicates higher risk in terms of short-term price fluctuations for IONS.Check SMMT's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, HALO has a market cap of 12.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while HALO trades at $107.20.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas HALO's P/E ratio is 20.00. In terms of profitability, IONS's ROE is -1.11%, compared to HALO's ROE of +1.81%. Regarding short-term risk, IONS is more volatile compared to HALO. This indicates higher risk in terms of short-term price fluctuations for IONS.Check HALO's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, BMRN has a market cap of 12.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while BMRN trades at $65.68.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas BMRN's P/E ratio is 31.58. In terms of profitability, IONS's ROE is -1.11%, compared to BMRN's ROE of +0.01%. Regarding short-term risk, IONS is more volatile compared to BMRN. This indicates higher risk in terms of short-term price fluctuations for IONS.Check BMRN's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, KRTX has a market cap of 12.6B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while KRTX trades at $329.83.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas KRTX's P/E ratio is -28.09. In terms of profitability, IONS's ROE is -1.11%, compared to KRTX's ROE of -0.36%. Regarding short-term risk, IONS is more volatile compared to KRTX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check KRTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, MDGL has a market cap of 12.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while MDGL trades at $534.49.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas MDGL's P/E ratio is -41.76. In terms of profitability, IONS's ROE is -1.11%, compared to MDGL's ROE of -0.57%. Regarding short-term risk, IONS is more volatile compared to MDGL. This indicates higher risk in terms of short-term price fluctuations for IONS.Check MDGL's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ARWR has a market cap of 11.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ARWR trades at $82.85.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ARWR's P/E ratio is -36.82. In terms of profitability, IONS's ROE is -1.11%, compared to ARWR's ROE of -0.61%. Regarding short-term risk, IONS is less volatile compared to ARWR. This indicates lower risk in terms of short-term price fluctuations for IONS.Check ARWR's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, AXSM has a market cap of 11.4B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while AXSM trades at $220.75.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas AXSM's P/E ratio is -57.64. In terms of profitability, IONS's ROE is -1.11%, compared to AXSM's ROE of -2.56%. Regarding short-term risk, IONS is less volatile compared to AXSM. This indicates lower risk in terms of short-term price fluctuations for IONS.Check AXSM's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, TECH has a market cap of 11.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while TECH trades at $72.12.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas TECH's P/E ratio is 37.18. In terms of profitability, IONS's ROE is -1.11%, compared to TECH's ROE of +0.09%. Regarding short-term risk, IONS is more volatile compared to TECH. This indicates higher risk in terms of short-term price fluctuations for IONS.Check TECH's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, RNAM has a market cap of 11.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while RNAM trades at $72.86.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas RNAM's P/E ratio is -17.39. In terms of profitability, IONS's ROE is -1.11%, compared to RNAM's ROE of -0.45%. Regarding short-term risk, IONS is more volatile compared to RNAM. This indicates higher risk in terms of short-term price fluctuations for IONS.Check RNAM's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, KRYS has a market cap of 10.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while KRYS trades at $347.00.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas KRYS's P/E ratio is 43.48. In terms of profitability, IONS's ROE is -1.11%, compared to KRYS's ROE of +0.19%. Regarding short-term risk, IONS is more volatile compared to KRYS. This indicates higher risk in terms of short-term price fluctuations for IONS.Check KRYS's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, RXDX has a market cap of 9.6B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while RXDX trades at $199.92.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas RXDX's P/E ratio is -56.47. In terms of profitability, IONS's ROE is -1.11%, compared to RXDX's ROE of -0.31%. Regarding short-term risk, IONS is more volatile compared to RXDX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check RXDX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, PTGX has a market cap of 9.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while PTGX trades at $148.18.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas PTGX's P/E ratio is 143.86. In terms of profitability, IONS's ROE is -1.11%, compared to PTGX's ROE of +0.12%. Regarding short-term risk, IONS is more volatile compared to PTGX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check PTGX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, KYMR has a market cap of 9.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while KYMR trades at $114.96.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas KYMR's P/E ratio is -35.92. In terms of profitability, IONS's ROE is -1.11%, compared to KYMR's ROE of -0.22%. Regarding short-term risk, IONS is less volatile compared to KYMR. This indicates lower risk in terms of short-term price fluctuations for IONS.Check KYMR's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, PRAX has a market cap of 9.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while PRAX trades at $334.58.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas PRAX's P/E ratio is -25.88. In terms of profitability, IONS's ROE is -1.11%, compared to PRAX's ROE of -0.34%. Regarding short-term risk, IONS is less volatile compared to PRAX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check PRAX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CYTK has a market cap of 9.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CYTK trades at $73.77.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CYTK's P/E ratio is -10.22. In terms of profitability, IONS's ROE is -1.11%, compared to CYTK's ROE of +1.64%. Regarding short-term risk, IONS is more volatile compared to CYTK. This indicates higher risk in terms of short-term price fluctuations for IONS.Check CYTK's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, NUVL has a market cap of 9.1B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while NUVL trades at $123.96.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas NUVL's P/E ratio is -21.79. In terms of profitability, IONS's ROE is -1.11%, compared to NUVL's ROE of -0.43%. Regarding short-term risk, IONS is more volatile compared to NUVL. This indicates higher risk in terms of short-term price fluctuations for IONS.Check NUVL's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CRNX has a market cap of 9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CRNX trades at $84.95.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CRNX's P/E ratio is -16.86. In terms of profitability, IONS's ROE is -1.11%, compared to CRNX's ROE of -0.44%. Regarding short-term risk, IONS is more volatile compared to CRNX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check CRNX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, IMGN has a market cap of 8.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while IMGN trades at $31.24.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas IMGN's P/E ratio is -111.55. In terms of profitability, IONS's ROE is -1.11%, compared to IMGN's ROE of -0.93%. Regarding short-term risk, IONS is more volatile compared to IMGN. This indicates higher risk in terms of short-term price fluctuations for IONS.Check IMGN's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ABVX has a market cap of 8.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ABVX trades at $118.64.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ABVX's P/E ratio is -62.19. In terms of profitability, IONS's ROE is -1.11%, compared to ABVX's ROE of -1.65%. Regarding short-term risk, IONS is less volatile compared to ABVX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check ABVX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, TXG has a market cap of 8.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while TXG trades at $68.59.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas TXG's P/E ratio is -116.25. In terms of profitability, IONS's ROE is -1.11%, compared to TXG's ROE of -0.09%. Regarding short-term risk, IONS is less volatile compared to TXG. This indicates lower risk in terms of short-term price fluctuations for IONS.Check TXG's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, PCVX has a market cap of 8.6B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while PCVX trades at $59.47.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas PCVX's P/E ratio is -7.79. In terms of profitability, IONS's ROE is -1.11%, compared to PCVX's ROE of -0.38%. Regarding short-term risk, IONS is more volatile compared to PCVX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check PCVX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, BPMC has a market cap of 8.4B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while BPMC trades at $129.46.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas BPMC's P/E ratio is -51.58. In terms of profitability, IONS's ROE is -1.11%, compared to BPMC's ROE of -0.31%. Regarding short-term risk, IONS is more volatile compared to BPMC. This indicates higher risk in terms of short-term price fluctuations for IONS.Check BPMC's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, APGE has a market cap of 8.4B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while APGE trades at $135.07.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas APGE's P/E ratio is -31.19. In terms of profitability, IONS's ROE is -1.11%, compared to APGE's ROE of -0.30%. Regarding short-term risk, IONS is more volatile compared to APGE. This indicates higher risk in terms of short-term price fluctuations for IONS.Check APGE's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, IBRX has a market cap of 8.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while IBRX trades at $7.91.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas IBRX's P/E ratio is -8.15. In terms of profitability, IONS's ROE is -1.11%, compared to IBRX's ROE of +1.35%. Regarding short-term risk, IONS is less volatile compared to IBRX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check IBRX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, TGTX has a market cap of 8.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while TGTX trades at $53.89.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas TGTX's P/E ratio is 19.53. In terms of profitability, IONS's ROE is -1.11%, compared to TGTX's ROE of +0.72%. Regarding short-term risk, IONS is less volatile compared to TGTX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check TGTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CERE has a market cap of 8.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CERE trades at $44.96.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CERE's P/E ratio is -16.47. In terms of profitability, IONS's ROE is -1.11%, compared to CERE's ROE of -0.72%. Regarding short-term risk, IONS is more volatile compared to CERE. This indicates higher risk in terms of short-term price fluctuations for IONS.Check CERE's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, TWST has a market cap of 7.9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while TWST trades at $127.22.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas TWST's P/E ratio is -57.31. In terms of profitability, IONS's ROE is -1.11%, compared to TWST's ROE of -0.30%. Regarding short-term risk, IONS is more volatile compared to TWST. This indicates higher risk in terms of short-term price fluctuations for IONS.Check TWST's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, SYRE has a market cap of 7.9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while SYRE trades at $90.60.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas SYRE's P/E ratio is -46.46. In terms of profitability, IONS's ROE is -1.11%, compared to SYRE's ROE of -0.24%. Regarding short-term risk, IONS is less volatile compared to SYRE. This indicates lower risk in terms of short-term price fluctuations for IONS.Check SYRE's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, IMVT has a market cap of 7.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while IMVT trades at $37.36.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas IMVT's P/E ratio is -13.25. In terms of profitability, IONS's ROE is -1.11%, compared to IMVT's ROE of -0.70%. Regarding short-term risk, IONS is less volatile compared to IMVT. This indicates lower risk in terms of short-term price fluctuations for IONS.Check IMVT's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, MTSR has a market cap of 7.4B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while MTSR trades at $70.50.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas MTSR's P/E ratio is -23.58. In terms of profitability, IONS's ROE is -1.11%, compared to MTSR's ROE of -0.61%. Regarding short-term risk, IONS is more volatile compared to MTSR. This indicates higher risk in terms of short-term price fluctuations for IONS.Check MTSR's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, RYTM has a market cap of 7.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while RYTM trades at $104.71.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas RYTM's P/E ratio is -33.67. In terms of profitability, IONS's ROE is -1.11%, compared to RYTM's ROE of -0.80%. Regarding short-term risk, IONS is less volatile compared to RYTM. This indicates lower risk in terms of short-term price fluctuations for IONS.Check RYTM's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, BLTE has a market cap of 7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while BLTE trades at $173.79.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas BLTE's P/E ratio is -92.94. In terms of profitability, IONS's ROE is -1.11%, compared to BLTE's ROE of -0.16%. Regarding short-term risk, IONS is less volatile compared to BLTE. This indicates lower risk in terms of short-term price fluctuations for IONS.Check BLTE's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CAI has a market cap of 6.9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CAI trades at $24.34.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CAI's P/E ratio is 68.39. In terms of profitability, IONS's ROE is -1.11%, compared to CAI's ROE of +0.19%. Regarding short-term risk, IONS is more volatile compared to CAI. This indicates higher risk in terms of short-term price fluctuations for IONS.Check CAI's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, MRUS has a market cap of 6.8B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while MRUS trades at $90.00.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas MRUS's P/E ratio is -17.05. In terms of profitability, IONS's ROE is -1.11%, compared to MRUS's ROE of -0.46%. Regarding short-term risk, IONS is more volatile compared to MRUS. This indicates higher risk in terms of short-term price fluctuations for IONS.Check MRUS's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ACLX has a market cap of 6.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ACLX trades at $115.07.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ACLX's P/E ratio is -28.27. In terms of profitability, IONS's ROE is -1.11%, compared to ACLX's ROE of -0.55%. Regarding short-term risk, IONS is more volatile compared to ACLX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ACLX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, SRRK has a market cap of 6.6B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while SRRK trades at $55.41.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas SRRK's P/E ratio is -16.06. In terms of profitability, IONS's ROE is -1.11%, compared to SRRK's ROE of -1.60%. Regarding short-term risk, IONS is similarly volatile compared to SRRK. This indicates similar risk in terms of short-term price fluctuations for IONS.Check SRRK's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, RETA has a market cap of 6.6B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while RETA trades at $172.36.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas RETA's P/E ratio is -66.29. In terms of profitability, IONS's ROE is -1.11%, compared to RETA's ROE of +0.47%. Regarding short-term risk, IONS is more volatile compared to RETA. This indicates higher risk in terms of short-term price fluctuations for IONS.Check RETA's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CGON has a market cap of 6.4B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CGON trades at $72.35.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CGON's P/E ratio is -26.90. In terms of profitability, IONS's ROE is -1.11%, compared to CGON's ROE of -0.25%. Regarding short-term risk, IONS is less volatile compared to CGON. This indicates lower risk in terms of short-term price fluctuations for IONS.Check CGON's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CNTA has a market cap of 6.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CNTA trades at $40.50.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CNTA's P/E ratio is -22.63. In terms of profitability, IONS's ROE is -1.11%, compared to CNTA's ROE of -0.60%. Regarding short-term risk, IONS is more volatile compared to CNTA. This indicates higher risk in terms of short-term price fluctuations for IONS.Check CNTA's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, TVTX has a market cap of 6.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while TVTX trades at $66.17.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas TVTX's P/E ratio is -147.04. In terms of profitability, IONS's ROE is -1.11%, compared to TVTX's ROE of -0.56%. Regarding short-term risk, IONS is less volatile compared to TVTX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check TVTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, MIRM has a market cap of 6B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while MIRM trades at $98.22.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas MIRM's P/E ratio is -6.75. In terms of profitability, IONS's ROE is -1.11%, compared to MIRM's ROE of -4.10%. Regarding short-term risk, IONS is less volatile compared to MIRM. This indicates lower risk in terms of short-term price fluctuations for IONS.Check MIRM's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, DNTH has a market cap of 5.9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while DNTH trades at $106.20.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas DNTH's P/E ratio is -25.59. In terms of profitability, IONS's ROE is -1.11%, compared to DNTH's ROE of -0.04%. Regarding short-term risk, IONS is less volatile compared to DNTH. This indicates lower risk in terms of short-term price fluctuations for IONS.Check DNTH's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, COGT has a market cap of 5.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while COGT trades at $33.41.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas COGT's P/E ratio is -15.83. In terms of profitability, IONS's ROE is -1.11%, compared to COGT's ROE of -0.73%. Regarding short-term risk, IONS is less volatile compared to COGT. This indicates lower risk in terms of short-term price fluctuations for IONS.Check COGT's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, LGND has a market cap of 5.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while LGND trades at $284.47.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas LGND's P/E ratio is 31.23. In terms of profitability, IONS's ROE is -1.11%, compared to LGND's ROE of +0.20%. Regarding short-term risk, IONS is more volatile compared to LGND. This indicates higher risk in terms of short-term price fluctuations for IONS.Check LGND's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, XENE has a market cap of 5.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while XENE trades at $58.65.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas XENE's P/E ratio is -12.48. In terms of profitability, IONS's ROE is -1.11%, compared to XENE's ROE of -0.44%. Regarding short-term risk, IONS is more volatile compared to XENE. This indicates higher risk in terms of short-term price fluctuations for IONS.Check XENE's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CDTX has a market cap of 5.6B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CDTX trades at $221.38.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CDTX's P/E ratio is -19.77. In terms of profitability, IONS's ROE is -1.11%, compared to CDTX's ROE of -0.37%. Regarding short-term risk, IONS is more volatile compared to CDTX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check CDTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ORKA has a market cap of 5.6B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ORKA trades at $92.38.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ORKA's P/E ratio is -47.62. In terms of profitability, IONS's ROE is -1.11%, compared to ORKA's ROE of -0.21%. Regarding short-term risk, IONS is less volatile compared to ORKA. This indicates lower risk in terms of short-term price fluctuations for IONS.Check ORKA's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ABCM has a market cap of 5.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ABCM trades at $23.99.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ABCM's P/E ratio is 2399.00. In terms of profitability, IONS's ROE is -1.11%, compared to ABCM's ROE of -0.01%. Regarding short-term risk, IONS is more volatile compared to ABCM. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ABCM's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, PTCT has a market cap of 5.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while PTCT trades at $66.06.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas PTCT's P/E ratio is -28.35. In terms of profitability, IONS's ROE is -1.11%, compared to PTCT's ROE of +0.22%. Regarding short-term risk, IONS is less volatile compared to PTCT. This indicates lower risk in terms of short-term price fluctuations for IONS.Check PTCT's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ERAS has a market cap of 5.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ERAS trades at $15.88.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ERAS's P/E ratio is -17.08. In terms of profitability, IONS's ROE is -1.11%, compared to ERAS's ROE of -0.80%. Regarding short-term risk, IONS is less volatile compared to ERAS. This indicates lower risk in terms of short-term price fluctuations for IONS.Check ERAS's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ISEE has a market cap of 5.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ISEE trades at $39.95.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ISEE's P/E ratio is -22.44. In terms of profitability, IONS's ROE is -1.11%, compared to ISEE's ROE of -0.39%. Regarding short-term risk, IONS is more volatile compared to ISEE. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ISEE's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, APLS has a market cap of 5.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while APLS trades at $41.03.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas APLS's P/E ratio is 38.35. In terms of profitability, IONS's ROE is -1.11%, compared to APLS's ROE of +0.40%. Regarding short-term risk, IONS is more volatile compared to APLS. This indicates higher risk in terms of short-term price fluctuations for IONS.Check APLS's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, DFTX has a market cap of 5.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while DFTX trades at $38.89.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas DFTX's P/E ratio is N/A. In terms of profitability, IONS's ROE is -1.11%, compared to DFTX's ROE of -0.85%. Regarding short-term risk, IONS is less volatile compared to DFTX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check DFTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CRSP has a market cap of 5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CRSP trades at $51.72.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CRSP's P/E ratio is -10.87. In terms of profitability, IONS's ROE is -1.11%, compared to CRSP's ROE of -0.24%. Regarding short-term risk, IONS is more volatile compared to CRSP. This indicates higher risk in terms of short-term price fluctuations for IONS.Check CRSP's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, EWTX has a market cap of 4.8B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while EWTX trades at $44.40.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas EWTX's P/E ratio is -24.00. In terms of profitability, IONS's ROE is -1.11%, compared to EWTX's ROE of -0.39%. Regarding short-term risk, IONS is less volatile compared to EWTX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check EWTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, TERN has a market cap of 4.8B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while TERN trades at $52.95.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas TERN's P/E ratio is -51.41. In terms of profitability, IONS's ROE is -1.11%, compared to TERN's ROE of -0.20%. Regarding short-term risk, IONS is more volatile compared to TERN. This indicates higher risk in terms of short-term price fluctuations for IONS.Check TERN's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ACAD has a market cap of 4.8B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ACAD trades at $27.83.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ACAD's P/E ratio is 12.54. In terms of profitability, IONS's ROE is -1.11%, compared to ACAD's ROE of +0.32%. Regarding short-term risk, IONS is more volatile compared to ACAD. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ACAD's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, FOLD has a market cap of 4.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while FOLD trades at $14.49.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas FOLD's P/E ratio is -161.00. In terms of profitability, IONS's ROE is -1.11%, compared to FOLD's ROE of -0.12%. Regarding short-term risk, IONS is more volatile compared to FOLD. This indicates higher risk in terms of short-term price fluctuations for IONS.Check FOLD's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, AKRO has a market cap of 4.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while AKRO trades at $54.65.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas AKRO's P/E ratio is -14.57. In terms of profitability, IONS's ROE is -1.11%, compared to AKRO's ROE of -0.22%. Regarding short-term risk, IONS is more volatile compared to AKRO. This indicates higher risk in terms of short-term price fluctuations for IONS.Check AKRO's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ALPN has a market cap of 4.5B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ALPN trades at $64.97.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ALPN's P/E ratio is -101.52. In terms of profitability, IONS's ROE is -1.11%, compared to ALPN's ROE of -0.13%. Regarding short-term risk, IONS is more volatile compared to ALPN. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ALPN's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, PBLS has a market cap of 4.3B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while PBLS trades at $36.88.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas PBLS's P/E ratio is -41.91. In terms of profitability, IONS's ROE is -1.11%, compared to PBLS's ROE of -0.15%. Regarding short-term risk, IONS is more volatile compared to PBLS. This indicates higher risk in terms of short-term price fluctuations for IONS.Check PBLS's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, OPT has a market cap of 4.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while OPT trades at $3.41.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas OPT's P/E ratio is -1.52. In terms of profitability, IONS's ROE is -1.11%, compared to OPT's ROE of +1.18%. Regarding short-term risk, IONS is more volatile compared to OPT. This indicates higher risk in terms of short-term price fluctuations for IONS.Check OPT's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, PRTC has a market cap of 4.2B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while PRTC trades at $17.38.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas PRTC's P/E ratio is -3.78. In terms of profitability, IONS's ROE is -1.11%, compared to PRTC's ROE of -0.32%. Regarding short-term risk, IONS is more volatile compared to PRTC. This indicates higher risk in terms of short-term price fluctuations for IONS.Check PRTC's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, MANE has a market cap of 4.1B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while MANE trades at $98.97.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas MANE's P/E ratio is -31.52. In terms of profitability, IONS's ROE is -1.11%, compared to MANE's ROE of -0.38%. Regarding short-term risk, IONS is more volatile compared to MANE. This indicates higher risk in terms of short-term price fluctuations for IONS.Check MANE's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, RLAY has a market cap of 4.1B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while RLAY trades at $18.87.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas RLAY's P/E ratio is -12.02. In terms of profitability, IONS's ROE is -1.11%, compared to RLAY's ROE of -0.42%. Regarding short-term risk, IONS is more volatile compared to RLAY. This indicates higher risk in terms of short-term price fluctuations for IONS.Check RLAY's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, MRTX has a market cap of 4.1B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while MRTX trades at $58.70.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas MRTX's P/E ratio is -4.82. In terms of profitability, IONS's ROE is -1.11%, compared to MRTX's ROE of -0.62%. Regarding short-term risk, IONS is more volatile compared to MRTX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check MRTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CELC has a market cap of 4.1B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CELC trades at $83.45.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CELC's P/E ratio is -19.41. In terms of profitability, IONS's ROE is -1.11%, compared to CELC's ROE of -3.51%. Regarding short-term risk, IONS is less volatile compared to CELC. This indicates lower risk in terms of short-term price fluctuations for IONS.Check CELC's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ELVN has a market cap of 3.9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ELVN trades at $54.32.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ELVN's P/E ratio is -32.53. In terms of profitability, IONS's ROE is -1.11%, compared to ELVN's ROE of -0.19%. Regarding short-term risk, IONS is less volatile compared to ELVN. This indicates lower risk in terms of short-term price fluctuations for IONS.Check ELVN's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, ADPT has a market cap of 3.9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while ADPT trades at $24.20.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas ADPT's P/E ratio is -59.02. In terms of profitability, IONS's ROE is -1.11%, compared to ADPT's ROE of -0.33%. Regarding short-term risk, IONS is more volatile compared to ADPT. This indicates higher risk in terms of short-term price fluctuations for IONS.Check ADPT's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, TNGX has a market cap of 3.9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while TNGX trades at $23.78.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas TNGX's P/E ratio is -28.65. In terms of profitability, IONS's ROE is -1.11%, compared to TNGX's ROE of -0.26%. Regarding short-term risk, IONS is less volatile compared to TNGX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check TNGX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CPRX has a market cap of 3.9B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CPRX trades at $31.49.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CPRX's P/E ratio is 12.30. In terms of profitability, IONS's ROE is -1.11%, compared to CPRX's ROE of +0.24%. Regarding short-term risk, IONS is more volatile compared to CPRX. This indicates higher risk in terms of short-term price fluctuations for IONS.Check CPRX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, IOVA has a market cap of 3.8B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while IOVA trades at $8.60.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas IOVA's P/E ratio is -11.78. In terms of profitability, IONS's ROE is -1.11%, compared to IOVA's ROE of -0.41%. Regarding short-term risk, IONS is less volatile compared to IOVA. This indicates lower risk in terms of short-term price fluctuations for IONS.Check IOVA's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, TLX has a market cap of 3.8B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while TLX trades at $11.29.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas TLX's P/E ratio is 117.85. In terms of profitability, IONS's ROE is -1.11%, compared to TLX's ROE of +0.07%. Regarding short-term risk, IONS is less volatile compared to TLX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check TLX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, RYZB has a market cap of 3.8B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while RYZB trades at $62.49.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas RYZB's P/E ratio is -57.86. In terms of profitability, IONS's ROE is -1.11%, compared to RYZB's ROE of +0.83%. Regarding short-term risk, IONS is more volatile compared to RYZB. This indicates higher risk in terms of short-term price fluctuations for IONS.Check RYZB's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, VKTX has a market cap of 3.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while VKTX trades at $31.98.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas VKTX's P/E ratio is -6.86. In terms of profitability, IONS's ROE is -1.11%, compared to VKTX's ROE of -0.95%. Regarding short-term risk, IONS is less volatile compared to VKTX. This indicates lower risk in terms of short-term price fluctuations for IONS.Check VKTX's competition here

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) plays a significant role within the Healthcare sector. Its performance on the NASDAQ reflects broader market trends and attracts considerable investor interest.

Comparing market capitalization, IONS stands at 9B. In comparison, CBAY has a market cap of 3.7B. Regarding current trading prices, IONS is priced at $54.21 on the NASDAQ, while CBAY trades at $32.48.

To assess relative profitability and valuation, we examine the Return on Equity (ROE) and Price-to-Earnings (P/E) ratios.

IONS currently has a P/E ratio of -31.52, whereas CBAY's P/E ratio is -32.81. In terms of profitability, IONS's ROE is -1.11%, compared to CBAY's ROE of -0.64%. Regarding short-term risk, IONS is more volatile compared to CBAY. This indicates higher risk in terms of short-term price fluctuations for IONS.Check CBAY's competition here